Article

Targeted suppression of SPP1 inhibits tumor invasion and metastasis in NRF2 hyperactivated cisplatin resistant HNSCC

2025-06-01

Abstract excerpt

<h4>Purpose</h4> Cisplatin is the gold standard systemic agent for definitive treatment of HNSCC. The purpose of this study was to investigate the role of SPP1 in the progression and metastasis of cisplatin-resistant HNSCC, particularly in the context of NRF2 hyperactivation. <h4>Experimental Design</h4> CDDP resistant HNSCC cell lines stably expressing various shRNA SPP1 constructs were generated. Clonogenic su...

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Literature Corpus work: 5efef809-ce30-5a8f-bcd7-7262f2b2e5fe
DOI: 10.1101/2025.05.28.656679

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