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Article

PI3Kinase based degradation of NRF2 signaling in chemo-radiation resistant HNSCC

2026-08-18

Abstract excerpt

<title>Abstract</title> <p> Background. Hyperactivation of NRF2 is an established factor contributing to chemoradiation resistance in head and neck squamous cell carcinoma (HNSCC). In tumors with <italic>KEAP1</italic> loss or mutations in the oncogenic <italic>PIK3CA</italic> pathway, NRF2 accumulates, enhancing antioxidant defenses that mitigate the cytotoxic effects of cisplatin and ionizing radiation. A...

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Literature Corpus work
dbfb4cff-e1f5-50ac-9f7b-4cdf97143367
DOI
10.21203/rs.3.rs-10606918/v1
Open publication

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PI3Kinase based degradation of NRF2 signaling in chemo-radiation resistant HNSCCDOI 10.21203/rs.3.rs-10606918/v1
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