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Targeting a miRNA–mRNA Regulatory Network to Overcome Radioresistance in Head and Neck Cancer: Identification of I-OMe-AG-538 via Transcriptome-Guided Drug Repurposing

2026-03-18

Abstract excerpt

<title>Abstract</title> <p>Radioresistance is a major obstacle to successful radiotherapy in head and neck cancer (HNC), leading to treatment failure, recurrence, and poor patient outcomes. MicroRNAs (miRNAs) are key post-transcriptional regulators implicated in radiosensitivity, but comprehensive miRNA–mRNA networks driving radioresistance in HNC remain poorly defined. Here, we established isogenic radioresistan...

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Literature Corpus work
e9adc5c2-472a-53c1-96b1-2668d197547d
DOI
10.21203/rs.3.rs-8888021/v1
Open publication

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Targeting a miRNA–mRNA Regulatory Network to Overcome Radioresistance in Head and Neck Cancer: Identification of I-OMe-AG-538 via Transcriptome-Guided Drug RepurposingDOI 10.21203/rs.3.rs-8888021/v1
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