Article

Myonuclear apoptosis underlies diaphragm atrophy in mechanically ventilated ICU patients

2024-07-24

Abstract excerpt

<h4>Rationale</h4> Mechanical ventilation plays an important role in critical illness-associated diaphragm weakness. Weakness contributes to difficult weaning and is associated with increased morbidity and mortality. Diaphragm weakness is caused by a combination of atrophy and dysfunction of myofibers, which are large syncytial cells maintained by a population of myonuclei. Each myonucleus provides gene transcript...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5b2573d-3505-5dc9-a568-47faca1aecd2
DOI: 10.1101/2024.07.23.24310792

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Myonuclear apoptosis underlies diaphragm atrophy in mechanically ventilated ICU patientsDOI 10.1101/2024.07.23.24310792Read

Myonuclear domains in muscle adaptation and diseaseSemantic proximity Read

RNA-sequencing reveals altered skeletal muscle contraction, E3 ligases, autophagy, apoptosis, and chaperone expression in patients with critical illness myopathySemantic proximity Read

Tumor-induced alterations in single-nucleus transcriptome of atrophying muscles indicate enhanced protein degradation and reduced oxidative metabolismSemantic proximity Read

Muscle wasting and the temporal gene expression pattern in a novel rat intensive care unit modelSemantic proximity Read

Integrated Single-Fiber Multi-Omics Links an Inflammatory-Associated Myofiber State to Altered Myosin Dynamics in Patients with ICU-acquired weaknessSemantic proximity Read

Clinical risk factors of intensive care unit acquired weakness predicted by human muscle microtissue response to humoral factorsSemantic proximity Read

Degenerative and regenerative pathways underlying Duchenne muscular dystrophy revealed by single-nucleus RNA sequencing.Semantic proximity Read

The myonuclear domain in adult skeletal muscle fibres: past, present and futureSemantic proximity Read

MicroRNA regulatory networks associated with abnormal muscle repair in survivors of critical illnessSemantic proximity Read

Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms.Semantic proximity Read

Altered muscle transcriptome as molecular basis of long-term muscle weakness in survivors from critical illnessSemantic proximity Read

Myosin Post-translational Modifications Associated with Critical Illness MyopathySemantic proximity Read