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The myonuclear domain in adult skeletal muscle fibres: past, present and future

11 Jan 2023

Abstract excerpt

Most cells in the body are mononuclear whereas skeletal muscle fibres are uniquely multinuclear. The nuclei of muscle fibres (myonuclei) are usually situated peripherally which complicates the equitable distribution of gene products. Myonuclear abundance can also change under conditions such as hypertrophy and atrophy. Specialised zones in muscle fibres have different functions and thus distinct synthetic demands...

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PMID: 36629254
DOI: 10.1113/jp283658

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