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Article

Degenerative and regenerative pathways underlying Duchenne muscular dystrophy revealed by single-nucleus RNA sequencing.

Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2020

Chemello Francesco, Wang Zhaoning, Li Hui, McAnally John R, Liu Ning, Bassel-Duby Rhonda, Olson Eric N

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a fatal muscle disorder characterized by cycles of degeneration and regeneration of multinucleated myofibers and pathological activation of a variety of other muscle-associated cell types. The extent to which different nuclei within the shared cytoplasm of a myofiber may display transcriptional diversity and whether individual nuclei within a multinucleated myofiber might...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscular Dystrophy, Animal

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Source

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Identifiers

PMID: 33148801
DOI: 10.1073/pnas.2018391117
PMCID: PMC7703557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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