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Article

Muscle wasting and the temporal gene expression pattern in a novel rat intensive care unit model

1 Dec 2011

Abstract excerpt

BACKGROUND: Acute quadriplegic myopathy (AQM) or critical illness myopathy (CIM) is frequently observed in intensive care unit (ICU) patients. To elucidate duration-dependent effects of the ICU intervention on molecular and functional networks that control the muscle wasting and weakness associated with AQM, a gene expression profile was analyzed at time points varying from 6 hours to 14 days in a unique...

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PMID: 22165895
DOI: 10.1186/1471-2164-12-602

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