Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA-sequencing reveals altered skeletal muscle contraction, E3 ligases, autophagy, apoptosis, and chaperone expression in patients with critical illness myopathy

16 Apr 2019

Abstract excerpt

BACKGROUND: Critical illness myopathy (CIM) is associated with severe skeletal muscle wasting and impaired function in intensive care unit (ICU) patients. The mechanisms underlying CIM remain incompletely understood. To elucidate the biological activities occurring at the transcriptional level in the skeletal muscle of ICU patients with CIM, the gene expression profiles, potential upstream regulators, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Intensive Care Unit Cognitive Disorders
Share to Muscle Physiology and Disorders
Share to Nutrition and Health in Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30992050
DOI: 10.1186/s13395-019-0194-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA-sequencing reveals altered skeletal muscle contraction, E3 ligases, autophagy, apoptosis, and chaperone expression in patients with critical illness myopathyPMID 30992050Read ↗

Transcriptomic analysis reveals abnormal muscle repair and remodeling in survivors of critical illness with sustained weaknessSemantic proximity Read ↗

Altered muscle transcriptome as molecular basis of long-term muscle weakness in survivors from critical illnessSemantic proximity Read ↗

Integrated Single-Fiber Multi-Omics Links an Inflammatory-Associated Myofiber State to Altered Myosin Dynamics in Patients with ICU-acquired weaknessSemantic proximity Read ↗

MicroRNA regulatory networks associated with abnormal muscle repair in survivors of critical illnessSemantic proximity Read ↗

Impaired autophagy, chaperone expression, and protein synthesis in response to critical illness interventions in porcine skeletal muscleSemantic proximity Read ↗

Myosin Post-translational Modifications Associated with Critical Illness MyopathySemantic proximity Read ↗

Clinical risk factors of intensive care unit acquired weakness predicted by human muscle microtissue response to humoral factorsSemantic proximity Read ↗

Muscle wasting and the temporal gene expression pattern in a novel rat intensive care unit modelSemantic proximity Read ↗

Ischaemia reperfusion injury in the pathogenesis of intensive care unit acquired weaknessSemantic proximity Read ↗

Post-COVID syndrome is associated with capillary alterations, macrophage infiltration and distinct transcriptomic signatures in skeletal musclesSemantic proximity Read ↗

Inflammation and altered metabolism impede efficacy of Functional Electrical Stimulation in critically ill patientsSemantic proximity Read ↗

MicroRNA-542 Promotes Mitochondrial Dysfunction and SMAD Activity and Is Elevated in Intensive Care Unit–acquired WeaknessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.