Article

Tumor-induced alterations in single-nucleus transcriptome of atrophying muscles indicate enhanced protein degradation and reduced oxidative metabolism

2023-10-26

Abstract excerpt

<h4>Summary</h4> Tumor-induced skeletal muscle wasting in the context of cancer cachexia is a condition with profound implications for patient survival. The loss of muscle mass is a significant clinical obstacle and is linked to reduced tolerance to chemotherapy and increased frailty. We investigated muscle gene expression at single nucleus level in cachectic mice and revealed distinct myonuclear gene signatures...

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Literature Corpus work: 304fc28d-3cbc-5db1-a20b-4f07b2551e87
DOI: 10.1101/2023.10.26.564119

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