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Article

Altered muscle transcriptome as molecular basis of long-term muscle weakness in survivors from critical illness

1 Jun 2025

Abstract excerpt

PURPOSE: Critically ill patients requiring intensive care unit (ICU) admission suffer from muscle weakness that persists for years, compromising quality-of-life. The pathophysiology of this long-term weakness remains unclear. We hypothesized that former ICU-patients show a long-term abnormal RNA-expression profile, which may contribute to lower long-term strength and for which modifiable risk factors can be...

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PMID: 40493222
DOI: 10.1007/s00134-025-07949-3

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