Article

Molecular Signatures of Resilience to Alzheimer’s Disease in Neocortical Layer 4 Neurons

2024-11-04

Abstract excerpt

<h4>ABSTRACT</h4> Single-cell omics is advancing our understanding of selective neuronal vulnerability in Alzheimer’s disease (AD), revealing specific subtypes that are either susceptible or resilient to neurodegeneration. Using single-nucleus and spatial transcriptomics to compare neocortical regions affected early (prefrontal cortex and precuneus) or late (primary visual cortex) in AD, we identified a resilient...

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Literature Corpus work: a5942ead-13b4-56c4-a696-03d0558077d2
DOI: 10.1101/2024.11.03.621787

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