Article

Mechanisms of resilience to autosomal dominant Alzheimer’s disease via oligogenic modulation of rare variants in the entorhinal cortex

2026-08-07

Abstract excerpt

Two PSEN1 E280A carriers have presented extreme protection against autosomal dominant Alzheimer’s disease (ADAD), with over two decades of delay for dementia onset. One of them, a male heterozygous for the RELN-COLBOS protective variant showed increased neuronal density in the entorhinal cortex 1 . We conducted a deep phenotyping and genotyping study of the entorhinal cortex in protected and unprotected PSEN1...

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Literature Corpus work: f054df8e-d08f-5412-b48b-c883f5ecfe4e
DOI: 10.64898/2026.08.03.742644

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