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African swine fever virus MGF505-7R protein interacted with IRF7and TBK1 to inhibit type I interferon production

18 Sept 2022

Abstract excerpt

African swine fever virus (ASFV) employs diverse strategies to confront or evade host type I interferon (IFN-I)-induced antiviral responses. Moreover, the mechanisms of this process are largely unknown. Here, we assessed 27 ASFV proteins to determine whether any of them suppressed the cGAS-STING pathway to facilitate immune evasion. Using dual-luciferase assays, we found that ASFV MGF505-7R suppressed the...

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PMID: 36130654
DOI: 10.1016/j.virusres.2022.198931

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