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African swine fever virus B175L inhibits the type I interferon pathway by targeting STING and 2′3′-cGAMP

30 Oct 2023

Abstract excerpt

ABSTRACT Type I interferon (IFN)-mediated responses operate a pivotal role in the first line of host immune defense against viruses. Upon DNA virus infection, DNA sensing cyclic GMP-AMP synthase-STING signal pathway is a key event in the IFN-mediated antiviral response and also a target of viral immune evasion. African swine fever (ASF) is a highly contagious, cross-border viral disease that often confers...

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PMID: 37902401
DOI: 10.1128/jvi.00795-23

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