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African swine fever virus S273R protein antagonizes type I interferon production by interfering with TBK1 and IRF3 interaction

31 Aug 2023

Abstract excerpt

African swine fever (ASF) is originally reported in East Africa as an acute hemorrhagic fever. African swine fever virus (ASFV) is a giant and complex DNA virus with icosahedral structure and encodes a variety of virulence factors to resist host innate immune response. S273R protein (pS273R), as a SUMO-1 specific cysteine protease, can affect viral packaging by cutting polymeric proteins. In this study, we found...

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PMID: 37659477
DOI: 10.1016/j.virs.2023.08.009

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