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Integrated Cross-Species Translation and Biophysical Multi-Scale Modeling Links Molecular Signatures and Locomotory Phenotypes in Spaceflight-Induced Sarcopenia

2025-05-08

Abstract excerpt

<h4>ABSTRACT</h4> Age-related skeletal muscle deterioration, referred to as sarcopenia, poses significant risks to astronaut health and mission success during spaceflight, yet its multisystem drivers remain poorly understood. While terrestrial sarcopenia manifests gradually through aging, spaceflight induces analogous musculoskeletal decline within weeks, providing an accelerated model to study conserved atrophy...

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Literature Corpus work
a57887ab-0479-58a4-9799-462298ea0fa6
DOI
10.1101/2025.05.03.652040
Open publication

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Integrated Cross-Species Translation and Biophysical Multi-Scale Modeling Links Molecular Signatures and Locomotory Phenotypes in Spaceflight-Induced SarcopeniaDOI 10.1101/2025.05.03.652040
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