Back to search

Article

MicroAge Mission: Effects of Microgravity and Heat Shock Protein 10 Overexpression on the Proteome of Human Tissue-Engineered Muscle Constructs - Implications for Skeletal Muscle Ageing

2026-04-30

Abstract excerpt

Age-related loss of skeletal muscle mass and function, or sarcopenia, presents a growing clinical challenge, mirroring the accelerated muscle atrophy seen in microgravity. This study, part of the UK Space Agency’s MicroAge Mission, aimed to investigate microgravity-induced proteomic changes in 3D human skeletal muscle constructs and assess whether mitochondrial Heat Shock Protein 10 (HSP10) overexpression could mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
33f9add9-65e9-5c16-b957-304724b3dfe4
DOI
10.64898/2026.04.27.721147
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
MicroAge Mission: Effects of Microgravity and Heat Shock Protein 10 Overexpression on the Proteome of Human Tissue-Engineered Muscle Constructs - Implications for Skeletal Muscle AgeingDOI 10.64898/2026.04.27.721147
MicroAge Mission: Experimental Design, Hardware Development and Operational Considerations for a Bespoke Culture System to Support Tissue-Engineered Skeletal Muscle ConstructsSemantic proximity
Microgravity Accelerates Skeletal Muscle Degeneration: Functional and Transcriptomic Insights from a Muscle Lab-on-Chip Model Onboard the ISSSemantic proximity
Microgravity and Human Body: Unraveling the Potential Role of Heat-Shock Proteins in Spaceflight and Future Space MissionsSemantic proximity
Validation of Human Skeletal Muscle Tissue Chip Autonomous Platform to Model Age-Related Muscle Wasting in MicrogravitySemantic proximity
Human skeletal muscle tissue chip autonomous payload reveals changes in fiber type and metabolic gene expression due to spaceflightSemantic proximity
Transcriptomic meta‐analysis of disuse muscle atrophy vs. resistance exercise‐induced hypertrophy in young and older humansSemantic proximity
Integrated Cross-Species Translation and Biophysical Multi-Scale Modeling Links Molecular Signatures and Locomotory Phenotypes in Spaceflight-Induced SarcopeniaSemantic proximity
Spaceflight-induced contractile and mitochondrial dysfunction in an automated heart-on-a-chip platformSemantic proximity
Spaceflight induced changes in the human proteomeSemantic proximity
A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance trainingSemantic proximity
Therapeutic potential of heat shock protein induction for muscular dystrophy and other muscle wasting conditionsSemantic proximity
Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loadingSemantic proximity
Select a neighboring publication to make it the new centre.