Article

Aging and putative frailty biomarkers are altered by spaceflight

2023-02-23

Abstract excerpt

<title>Abstract</title> <p>Human space exploration is hazardous, causing molecular changes that can alter astronauts' health. This can include genomic instability, mitochondrial dysfunction, increased inflammation, homeostatic dysregulation, and epigenomic changes. These alterations are similar to changes during aging on Earth. However, little is known about the link between these changes and disease development...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f5d58c95-6a61-51cc-81fe-99ad0da8842d
DOI: 10.21203/rs.3.rs-2512123/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aging and putative frailty biomarkers are altered by spaceflightDOI 10.21203/rs.3.rs-2512123/v1Read

Aging and putative frailty biomarkers are altered by spaceflightSemantic proximity Read

Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflightSemantic proximity Read

Microgravity Remodels Longevity Networks in Astronaut PBMCs: Integrated Findings of Telomere Elongation, DNA Repair Responses, and miRNA SuppressionSemantic proximity Read

Longitudinal transcriptomic and epigenetic analysis in astronauts reveals dynamic immune response to spaceflightSemantic proximity Read

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependentSemantic proximity Read

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflightSemantic proximity Read

Telomeres and aging: on and off the planet!Semantic proximity Read

Spatially resolved multiomics on the neuronal effects induced by spaceflightSemantic proximity Read

Systemic Genome Correlation Loss as a Central Characteristic of SpaceflightSemantic proximity Read

Spaceflight modulates gene expression in the whole blood of astronautsSemantic proximity Read

Using single-sample networks to identify the contrasting patterns of gene interactions and reveal the radiation dose-dependent effects in multiple tissues of spaceflight miceSemantic proximity Read

Key Genes, Altered Pathways and Potential Treatments for Muscle Loss in Astronauts and Sarcopenic PatientsSemantic proximity Read