Article

Microgravity Accelerates Skeletal Muscle Degeneration: Functional and Transcriptomic Insights from a Muscle Lab-on-Chip Model Onboard the ISS

2025-01-27

Abstract excerpt

<h4>ABSTRACT</h4> Microgravity accelerates skeletal muscle degeneration, mimicking aging, yet its effects on human muscle cell function and signaling remain underexplored. Using a muscle lab-on-chip model onboard the International Space Station, we examined how microgravity and electrically stimulated contractions influence muscle biology and age-related muscle changes. Our 3D bioengineered muscle model, cultured...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f50db48-1cd9-5b92-ba38-698cbf6a0507
DOI: 10.1101/2025.01.26.634580

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Microgravity Accelerates Skeletal Muscle Degeneration: Functional and Transcriptomic Insights from a Muscle Lab-on-Chip Model Onboard the ISSDOI 10.1101/2025.01.26.634580Read

Validation of Human Skeletal Muscle Tissue Chip Autonomous Platform to Model Age-Related Muscle Wasting in MicrogravitySemantic proximity Read

Human skeletal muscle tissue chip autonomous payload reveals changes in fiber type and metabolic gene expression due to spaceflightSemantic proximity Read

MicroAge Mission: Experimental Design, Hardware Development and Operational Considerations for a Bespoke Culture System to Support Tissue-Engineered Skeletal Muscle ConstructsSemantic proximity Read

MicroAge Mission: Effects of Microgravity and Heat Shock Protein 10 Overexpression on the Proteome of Human Tissue-Engineered Muscle Constructs - Implications for Skeletal Muscle AgeingSemantic proximity Read

Integrated Cross-Species Translation and Biophysical Multi-Scale Modeling Links Molecular Signatures and Locomotory Phenotypes in Spaceflight-Induced SarcopeniaSemantic proximity Read

Spaceflight-induced contractile and mitochondrial dysfunction in an automated heart-on-a-chip platformSemantic proximity Read

Simulated microgravity accelerates aging of human skeletal muscle myoblasts at the single cell levelSemantic proximity Read

Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loadingSemantic proximity Read

Integrated Single-Fiber Multi-Omics Links an Inflammatory-Associated Myofiber State to Altered Myosin Dynamics in Patients with ICU-acquired weaknessSemantic proximity Read

Human skeletal muscle ageing atlasSemantic proximity Read

A network-based atlas of human skeletal muscle agingSemantic proximity Read

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependentSemantic proximity Read