Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia.

Abstract excerpt

Sarcopenia, the age-related loss of skeletal muscle mass and function, affects 5-13% of individuals aged over 60 years. While rodents are widely-used model organisms, which aspects of sarcopenia are recapitulated in different animal models is unknown. Here we generated a time series of phenotypic measurements and RNA sequencing data in mouse gastrocnemius muscle and analyzed them alongside analogous data from...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Age Factors
• Share to Aging