Article
Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation.
Neurobiology of disease - 1 Oct 2017
Reilly Patrick, Winston Charisse N, Baron Kelsey R, Trejo Margarita, Rockenstein Edward M, Akers Johnny C, Kfoury Najla, Diamond Marc, Masliah Eliezer, Rissman Robert A, Yuan Shauna H
Abstract excerpt
Tauopathies are a class of neurodegenerative diseases, including Alzheimer's disease, frontotemporal dementia and progressive supranuclear palsy, which are associated with the pathological aggregation of tau protein into neurofibrillary tangles (NFT). Studies have characterized tau as a "prion-like" protein given its ability to form distinct, stable amyloid conformations capable of transcellular and...
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