Article

Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer

2023-09-28

Abstract excerpt

Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA translation represents an attractive cancer therapy. Here, we show that therapeutically targeting the RNA helicase eIF4A by Zotatifin, the first-in-class eIF4A inhibitor, exerts pleiotropic effects on both tumor cells and the tumor immune microenvironment in a diverse cohort of syngeneic triple-negative breast cancer (TNBC) mou...

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Literature Corpus work: 02d59123-f4a4-55b1-b45c-6251560c1799
DOI: 10.1101/2023.09.28.559973

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