Article

Homozygous Deletions at Chromosome 9p21 Involving p16 and p15 Are Associated With Histologic Progression in Follicle Center Lymphoma

1998-06-15

Abstract excerpt

Low-grade follicle center lymphoma (LGFCL) is characterized genetically by the t(14;18) translocation and an indolent clinical course. Histologic progression from LGFCL to an aggressive diffuse large B-cell lymphoma (DLCL) occurs in 60% to 80% of cases, and this transformation is associated with the accumulation of secondary genetic alterations. Using 10 polymorphic microsatellite markers spanning the chromosome 9...

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Literature Corpus work: a543e7fd-76c3-5f5e-9bd2-6f81018ef742
DOI: 10.1182/blood.v91.12.4677.412k40_4677_4685

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