Article
p53 mutation is associated with progression in follicular lymphomas.
Blood - 1 Oct 1993
Sander C A, Yano T, Clark H M, Harris C, Longo D L, Jaffe E S, Raffeld M
Abstract excerpt
The majority of low-grade follicular lymphomas will eventually transform to an aggressive intermediate, or high-grade lymphoma. The molecular mechanisms responsible for this transformation have not been determined. We studied serial biopsies from 34 patients with follicular lymphomas that underwent histologic transformation, for abnormalities of the p53 tumor suppressor gene by a combination of...
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