Article
p16(INK4a) is selectively silenced in the tumoral progression of mycosis fungoides.
Laboratory investigation; a journal of technical methods and pathology - 1 Feb 2002
Navas Inmaculada C, Algara Patrocinio, Mateo Marisol, Martínez Pedro, García Carmen, Rodriguez Jose L, Vanaclocha Francisco, Barrientos Nuria, Iglesias Luis, Sánchez Lydia, Piris Miguel A, Ortiz-Romero Pablo
Abstract excerpt
Knowledge about the molecular mechanisms involved in the pathogenesis of tumoral progression in mycosis fungoides (MF) is still scarce. Because the 9p21 locus seems to be a good target for a detailed study in MF, this prompted us to compare the mechanisms of inactivation of the p16(INK4a), p15(INK4b), and p14(ARF) genes in aggressive and stable forms of MF, performing microsatellite analysis, methylation-specific...
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