Article
p53 mutations are associated with histologic transformation of follicular lymphoma.
Blood - 15 Oct 1993
Lo Coco F, Gaidano G, Louie D C, Offit K, Chaganti R S, Dalla-Favera R
Abstract excerpt
The majority of low-grade non-Hodgkin's lymphomas (NHL) undergo clinical progression toward intermediate- and high-grade lymphomas. This progression is often associated with histologic transformation from follicular to diffuse-type NHL. The pathogenetic mechanisms underlying this evolution are presently unknown. In this study, we have analyzed the role in NHL progression of relevant genetic lesions affecting...
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