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Article

Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo.

Neurobiology of disease - 1 Jul 2020

Gogia Neha, Sarkar Ankita, Mehta Abijeet Singh, Ramesh Nandini, Deshpande Prajakta, Kango-Singh Madhuri, Pandey Udai Bhan, Singh Amit

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS), a late-onset neurodegenerative disorder characterized by the loss of motor neurons in the central nervous system, has no known cure to-date. Disease causing mutations in human Fused in Sarcoma (FUS) leads to aggressive and juvenile onset of ALS. FUS is a well-conserved protein across different species, which plays a crucial role in regulating different aspects of RNA...

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Identifiers

PMID: 32199908
DOI: 10.1016/j.nbd.2020.104837
PMCID: PMC9277911

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Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo.PMID 32199908Read ↗

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