Article

Bromodomain factor 5 is an essential transcriptional regulator of the <i>Leishmania</i> genome

2021-09-30

Abstract excerpt

Leishmania are unicellular parasites that cause human and animal disease. Alongside other organisms in kinetoplastida, they have evolved an unusual genome architecture that requires all RNA polymerase II transcribed genes to be expressed constitutively, with transcriptional start regions denoted by histone variants and histone lysine acetylation. However, the way these chromatin marks are interpreted by the cell i...

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Literature Corpus work: a5226ade-7395-5abd-a062-d0f056e4e114
DOI: 10.1101/2021.09.29.462384

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