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Structural Insights into Bromodomain-Containing Complexes from <i>Trypanosoma cruzi</i> Revealed by Proximity Labeling and Stoichiometric Space Exploration

2026-03-25

Abstract excerpt

Trypanosoma cruzi is the causative agent of Chagas disease, a neglected illness with outdated treatments. Bromodomain factors (BDFs) are essential proteins that recognize acetylated lysines and have strong therapeutic potential. They form part of epigenetic complexes that regulate chromatin accessibility and, therefore, gene expression. However, little is known about their structure in trypanosomatids. Here, we us...

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Literature Corpus work
942b4919-05b1-56f9-97a1-f65188a9830f
DOI
10.64898/2026.03.22.713544
Open publication

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Structural Insights into Bromodomain-Containing Complexes from <i>Trypanosoma cruzi</i> Revealed by Proximity Labeling and Stoichiometric Space ExplorationDOI 10.64898/2026.03.22.713544
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