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Essential Bromodomain Tc BDF2 as a Drug Target against Chagas Disease

28 Apr 2022

Abstract excerpt

Trypanosoma cruzi is a unicellular parasite that causes Chagas disease, which is endemic in the American continent but also worldwide, distributed by migratory movements. A striking feature of trypanosomatids is the polycistronic transcription associated with post-transcriptional mechanisms that regulate the levels of translatable mRNA. In this context, epigenetic regulatory mechanisms have been revealed to be of...

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PMID: 35482332
DOI: 10.1021/acsinfecdis.2c00057

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