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Bromodomain factor 5 is an essential regulator of transcription in Leishmania

13 Jul 2022

Abstract excerpt

Leishmania are unicellular parasites that cause human and animal diseases. Like other kinetoplastids, they possess large transcriptional start regions (TSRs) which are defined by histone variants and histone lysine acetylation. Cellular interpretation of these chromatin marks is not well understood. Eight bromodomain factors, the reader modules for acetyl-lysine, are found across Leishmania genomes. Using L....

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PMID: 35831302
DOI: 10.1038/s41467-022-31742-1

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