Back to search

Article

Distinct features of the <i>Leishmania</i> cap-binding protein LeishIF4E2 revealed by CRISPR-Cas9 mediated heterozygous deletion

2020-05-13

Abstract excerpt

Leishmania parasites cycle between sand-fly vectors and mammalian hosts, adapting to alternating environments by stage-differentiation, accompanied by changes in the proteome profiles. Translation regulation plays a central role in driving the differential program of gene expression, since control of gene regulation in Leishmania is mostly post-transcriptional. The Leishmania genome encodes six eIF4E candidates,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1a3d11ee-7aa3-5ef1-9219-fe1221135f27
DOI
10.1101/2020.05.13.093914
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Distinct features of the <i>Leishmania</i> cap-binding protein LeishIF4E2 revealed by CRISPR-Cas9 mediated heterozygous deletionDOI 10.1101/2020.05.13.093914
LeishIF4E1 Deletion Affects the Promastigote Proteome, Morphology, and InfectivitySemantic proximity
Deletion of a Single LeishIF4E-3 Allele by the CRISPR-Cas9 System Alters Cell Morphology and Infectivity of LeishmaniaSemantic proximity
LeishIF4E-5 Is a Promastigote-Specific Cap-Binding Protein in LeishmaniaSemantic proximity
A novel <i>Leishmania infantum</i> reference strain for gene editing and the study of visceral leishmaniasisSemantic proximity
<i>Leishmania</i> differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complexSemantic proximity
Bromodomain factor 5 is an essential transcriptional regulator of the <i>Leishmania</i> genomeSemantic proximity
<i>In vivo</i> single-cell CRISPR screening for microproteins identifies a critical ribosomal componentSemantic proximity
mRNA cap-binding protein eIF4E1 is a novel regulator of <i>Toxoplasma gondii</i> latencySemantic proximity
The mRNA-bound proteome of <i>Leishmania mexicana</i> : novel genetic insight into an ancient parasiteSemantic proximity
<i>In vivo</i> CRISPR screens identify novel virulence genes among proteins of unassigned subcellular localization in <i>Toxoplasma</i>Semantic proximity
Comparative and systems analyses of <i>Leishmania</i> spp. non-coding RNAs through developmental stagesSemantic proximity
Genome-wide mapping of RPA1 and RAD9 reveals the management of polycistronic transcription, replication initiation, and responses to replication stress in <i>Leishmania</i>Semantic proximity
Select a neighboring publication to make it the new centre.