Article
webTWAS 2.0: update platform for identifying complex disease susceptibility genes through transcriptome-wide association study.
Nucleic acids research - 6 Jan 2025
Cao Chen, Shao Mengting, Wang Jianhua, Li Zhenghui, Chen Haoran, You Tianyi, Li Mulin Jun, Ding Yijie, Zou Quan
Abstract excerpt
Transcriptome-wide association study (TWAS) has successfully identified numerous complex disease susceptibility genes in the post-genome-wide association study (GWAS) era. Over the past 3 years, the focus of TWAS algorithms has shifted from merely identifying associations to understanding how single nucleotide polymorphisms (SNPs) regulate gene expression, with a growing emphasis on incorporating fine-mapping...
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