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Article

Statistical power of transcriptome-wide association studies.

Genetic epidemiology - 1 Dec 2022

He Ruoyu, Xue Haoran, Pan Wei

Abstract excerpt

Transcriptome-Wide Association Studies (TWASs) have become increasingly popular in identifying genes (or other endophenotypes or exposures) associated with complex traits. In TWAS, one first builds a predictive model for gene expressions using an expression quantitative trait loci (eQTL) data set in stage 1, then tests the association between the predicted gene expression and a trait based on a large, independent...

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PMID: 35766062
DOI: 10.1002/gepi.22491
PMCID: PMC9669108

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