Article

Single-cell and spatial transcriptomics uncovers the role of senescent vascular cells in pathological arterial remodeling during murine atherosclerosis

2024-10-30

Abstract excerpt

<title>Abstract</title> <p>Studying cardiovascular senescence is crucial for understanding disease-related changes in the cardiovascular system and their impact on health and disease. To systematically investigate the heterogeneity of senescent vascular cells in atherosclerosis, we employed the senescence reporter mouse p16tdTomato+/-, overexpressed PCSK9 and fed a high-fat diet (HFD) to induce atherosclerosis, a...

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Literature Corpus work: 368193b8-fc78-5ba7-b49f-daa9ce077b91
DOI: 10.21203/rs.3.rs-4282827/v1

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