Back to search

Article

Total whole-arm chromosome losses predict malignancy in human cancer

2025-03-11

Abstract excerpt

Aneuploidy is observed as gains or losses of whole chromosomes or chromosome arms and is a common hallmark of cancer. Whereas models for the generation of aneuploidy in cancer invoke mitotic chromosome segregation errors, whole-arm losses might occur simply as a result of centromere breakage. We recently showed that elevated RNA Polymerase II (RNAPII) level over S-phase-dependent histone genes predicts rapid recur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a4d95965-6b0c-51f4-8bd9-ffc2d0a9cfdd
DOI
10.1101/2025.03.09.642243
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Total whole-arm chromosome losses predict malignancy in human cancerDOI 10.1101/2025.03.09.642243
Integrating gene expression, mutation and copy number data to identify driver genes of recurrent chromosome-arm lossesSemantic proximity
Extensive protein dosage compensation in aneuploid human cancersSemantic proximity
Genome-wide Chromosome-specific Aneuploidy Engineering and Phenotypic Characterization with CRISPR-TaijiSemantic proximity
Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor.Semantic proximity
Patterns of Aneuploidy and Signaling Consequences in CancerSemantic proximity
Non-Random Mis-Segregation of Human ChromosomesSemantic proximity
Single-cell and bulk RNA sequencing analysis reveals CENPA as a potential biomarker and therapeutic target in cancersSemantic proximity
The presence of extra chromosomes leads to genomic instability.Semantic proximity
Chromosome Abnormalities: New Insights into Their Clinical Significance in CancerSemantic proximity
Single-Cell and Bulk RNA Sequencing Analysis Reveals CENPA as a Potential Biomarker and Therapeutic Target in CancersSemantic proximity
Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast CancerSemantic proximity
Unraveling pathologies underlying chromosomal instability in cancers.Semantic proximity
Select a neighboring publication to make it the new centre.