Article
Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor.
Genome medicine - 28 Apr 2020
Quevedo Rene, Spreafico Anna, Bruce Jeff, Danesh Arnavaz, El Ghamrasni Samah, Giesler Amanda, Hanna Youstina, Have Cherry, Li Tiantian, Yang S Y Cindy, Zhang Tong, Asa Sylvia L, Haibe-Kains Benjamin, Krzyzanowska Monika, Smith Adam C, Singh Simron, Siu Lillian L, Pugh Trevor J
Abstract excerpt
BACKGROUND: Pancreatic neuroendocrine tumors (PANETs) are rare, slow growing cancers that often present with local and distant metastasis upon detection. PANETS contain distinct karyotypes, epigenetic dysregulation, and recurrent mutations in MEN1, ATRX, and DAXX (MAD+); however, the molecular basis of disease progression remains uncharacterized. METHODS: We evaluated associations between aneuploidy and the MAD+...
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