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Chromosome Abnormalities: New Insights into Their Clinical Significance in Cancer

26 May 2020

Abstract excerpt

Chromosomal abnormalities, consisting of numerical and structural chromosome abnormalities, are a common characteristic of cancer. Numerical chromosome abnormalities, mainly including aneuploidy and chromosome instability, are caused by chromosome segregation errors in mitosis, whereas structural chromosome abnormalities are a consequence of DNA damage and comprise focal/arm-level chromosome gain or loss. Recent...

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PMID: 32637574
DOI: 10.1016/j.omto.2020.05.010

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