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Article

MADloy: robust detection of mosaic loss of chromosome Y from genotype-array-intensity data.

BMC bioinformatics - 23 Nov 2020

González Juan R, López-Sánchez Marcos, Cáceres Alejandro, Puig Pere, Esko Tonu, Pérez-Jurado Luis A

Abstract excerpt

BACKGROUND: Accurate protocols and methods to robustly detect the mosaic loss of chromosome Y (mLOY) are needed given its reported role in cancer, several age-related disorders and overall male mortality. Intensity SNP-array data have been used to infer mLOY status and to determine its prominent role in male disease. However, discrepancies of reported findings can be due to the uncertainty and variability of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33225898
DOI: 10.1186/s12859-020-03768-z
PMCID: PMC7682048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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