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Article

Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health.

Progress in biophysics and molecular biology - 1 Sept 2017

Jubb Harry C, Pandurangan Arun P, Turner Meghan A, Ochoa-Montaño Bernardo, Blundell Tom L, Ascher David B

Abstract excerpt

Many essential biological processes including cell regulation and signalling are mediated through the assembly of protein complexes. Changes to protein-protein interaction (PPI) interfaces can affect the formation of multiprotein complexes, and consequently lead to disruptions in interconnected networks of PPIs within and between cells, further leading to phenotypic changes as functional interactions are created...

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PMID: 27913149
DOI: 10.1016/j.pbiomolbio.2016.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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