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Article

Fine-tuning pH sensor H98 by remote essential residues in the hydrogen-bond network of mTASK-3.

International journal of biological macromolecules - 1 Jul 2024

Fan Xueming, Ye Yifei, Saha Aakash, Peng Li, Pindi Chinmai, Wang Qi, Yang Linghui, Liu Jin, Tang Xiangdong, Palermo Giulia, Liao Jiayu, Xu Tingting, Lu Yongzhi, Du Guizhi

Abstract excerpt

TASK-3 generates a background K+ conductance which when inhibited by acidification depolarizes membrane potential and increases cell excitability. These channels sense pH by protonation of histidine residue H98, but recent evidence revealed that several other amino acid residues also contribute to TASK-3 pH sensitivity, suggesting that the pH sensitivity is determined by an intermolecular network. Here we use...

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Identifiers

PMID: 38878921
DOI: 10.1016/j.ijbiomac.2024.132892
PMCID: PMC11583903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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