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Article

The pH-Dependent Trigger in Diphtheria Toxin T Domain Comes with a Safety Latch.

Biophysical journal - 1 Nov 2016

Rodnin Mykola V, Li Jing, Gross Michael L, Ladokhin Alexey S

Abstract excerpt

Protein-side-chain protonation, coupled to conformational rearrangements, is one way of regulating physiological function caused by changes in protein environment. Specifically, protonation of histidine residues has been implicated in pH-dependent conformational switching in several systems, including the diphtheria toxin translocation (T) domain, which is responsible for the toxin's cellular entry via the...

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Identifiers

PMID: 27806276
DOI: 10.1016/j.bpj.2016.09.030
PMCID: PMC5103022

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