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Article

Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii.

mBio - 13 Aug 2025

Short Francesca L, Maharjan Ram, Li Liping, Afrin Nusrat, Delgado Natasha, Boinett Christine J, Parkhill Julian, Cain Amy K, Paulsen Ian T

Abstract excerpt

Mutation rates in bacteria are an important determinant of adaptation to new environments and success in different niches. In some bacterial pathogens, "hypermutator" variants-most often associated with mutations in components of the DNA mismatch repair system-are associated with increased antibiotic resistance and poorer patient outcomes. We report the serendipitous finding of novel hypermutator genes in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40576344
DOI: 10.1128/mbio.00966-25
PMCID: PMC12345246

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