Article
General and inducible hypermutation facilitate parallel adaptation in Pseudomonas aeruginosa despite divergent mutation spectra.
Proceedings of the National Academy of Sciences of the United States of America - 21 Aug 2012
Weigand Michael R, Sundin George W
Abstract excerpt
The successful growth of hypermutator strains of bacteria contradicts a clear preference for lower mutation rates observed in the microbial world. Whether by general DNA repair deficiency or the inducible action of low-fidelity DNA polymerases, the evolutionary strategies of bacteria include methods of hypermutation. Although both raise mutation rate, general and inducible hypermutation operate through distinct...
Topics
- Acclimatization
- Bacterial Proteins
- DNA Mutational Analysis
- DNA Repair
- DNA-Directed DNA Polymerase
- Genome
- Genome, Bacterial
- Models, Genetic
- Molecular Sequence Data
- Mutation