Article

Cdkn2a/p16INK4A Loss Impairs Spatial Memory in Young Adult Mice Independently of Alzheimer ’s-Associated Genetic Pathways

2025-07-17

Abstract excerpt

<title>Abstract</title> <p>The cyclin-dependent kinase inhibitor CDKN2A/p16INK4A is a central regulator of cellular senescence, widely studied in ageing and cancer. Although its expression increases with age and disease, its role in the adult brain remains poorly defined. Recent evidence suggests a possible contribution to neuroinflammation and cognitive decline in Alzheimer’s disease (AD), but underlying mechani...

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Literature Corpus work: a461c5ed-d33d-55fb-9246-2ecc2097cb24
DOI: 10.21203/rs.3.rs-7058771/v1

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Cdkn2a/p16INK4A Loss Impairs Spatial Memory in Young Adult Mice Independently of Alzheimer ’s-Associated Genetic PathwaysDOI 10.21203/rs.3.rs-7058771/v1Read

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