Article

Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model

2022-03-21

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disease observed with aging that represents the most common form of dementia. To date, therapies targeting end-stage disease plaques, tangles, or inflammation have limited efficacy. Therefore, we set out to identify a potential earlier targetable phenotype. Utilizing a mouse model of AD and human fetal cells harboring mutant amyloid precursor protein, we...

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Literature Corpus work: 94a97237-a3f7-5b9d-9a68-e205e6d5aa4d
DOI: 10.7554/elife.66037

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