Article

Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer's model

2020-12-22

Abstract excerpt

Alzheimers disease (AD) is a progressive neurodegenerative disease observed with aging that represents the most common form of dementia. To date, therapies targeting end-stage disease plaques, tangles, or inflammation have limited efficacy. Therefore, we set out to identify an earlier targetable phenotype. Utilizing a mouse model of AD and human fetal cells harboring mutant amyloid precursor protein, we show cell...

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Literature Corpus work: b2ff1600-5d45-5ed1-b196-116c6d6c2c36
DOI: 10.1101/2020.12.21.383059

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