Article

Partially methylated domains are hallmarks of a cell specific epigenome topology

2018-01-17

Abstract excerpt

<h4>Background</h4> Partially methylated domains, PMDs, are extended regions in the genome exhibiting a reduced average DNA-methylation level. PMDs cover gene-poor and transcriptionally inactive regions and tend to be heterochromatic. Here, we present a first comprehensive comparative analysis of PMDs across more than 190 WGBS methylomes of human and mouse cells providing a deep insight into structural and functi...

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Literature Corpus work: 842ae012-01dc-50e7-b045-7abc42482ed6
DOI: 10.1101/249334

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