Article

TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brain

2023-03-18

Abstract excerpt

TREM2 and APOE are two major risk factors for Alzheimer’s disease (AD) that have been proposed to play crucial roles in microglia pathophysiology by affecting their ability to phagocytose cellular debris or aggregated proteins. In this study, we investigated for the first time the impact of TREM2 and APOE on the removal of dying neurons in the live brain by implementing a targeted photochemical method for programm...

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Literature Corpus work: a49790c5-c44b-57f4-b4ab-b3d16effa1b4
DOI: 10.1101/2023.03.17.533222

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TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brainDOI 10.1101/2023.03.17.533222Read

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