Article

BCG vaccination mitigates tau pathology and restores cognitive function in PS19 mice

2026-05-15

Abstract excerpt

Retrospective studies in patients with non-muscle invasive bladder cancer (NMIBC) have reported a significant reduction in Alzheimer’s disease (AD) incidence (12–78%) among Bacillus Calmette-Guérin (BCG) recipients versus controls. To investigate the underlying mechanisms, we evaluated BCG in the PS19 mouse model of tauopathy. We found that BCG administration reduced hippocampal phospho–tau and microgliosis while...

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Identifiers and source

Literature Corpus work: a43e467b-c1fe-562a-9f31-54303479a335
DOI: 10.64898/2026.05.12.724591

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